The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana
Identifieur interne : 000434 ( Main/Exploration ); précédent : 000433; suivant : 000435The Immunostimulatory and Antimicrobial Property of Two Herbal Decoctions Used in the Management of HIV/AIDS in Ghana
Auteurs : George Asumeng Koffuor [Ghana] ; Rita Dickson [Ghana] ; Stephen Yao Gbedema [Ghana] ; Edmund Ekuadzi [Ghana] ; Gabriel Dapaah [Ghana] ; Lydia Francisca Otoo [Ghana]Source :
- African Journal of Traditional, Complementary, and Alternative Medicines [ 0189-6016 ] ; 2014.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adjuvants immunologiques (pharmacologie), Adulte, Adulte d'âge moyen, Animaux, Anti-infectieux (administration et posologie), Anti-infectieux (pharmacologie), Bactéries à Gram positif (), Betula (), Candida albicans (), Extraits de plantes (administration et posologie), Extraits de plantes (pharmacologie), Fabaceae (), Femelle, Ghana, Humains, Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Jeune adulte, Mâle, Souris, Souris de lignée ICR, Syndrome d'immunodéficience acquise (immunologie), Syndrome d'immunodéficience acquise (traitement médicamenteux), Tests de sensibilité microbienne.
- MESH :
- administration et posologie : Adjuvants immunologiques, Anti-infectieux, Extraits de plantes.
- immunologie : Infections à VIH, Syndrome d'immunodéficience acquise.
- pharmacologie : Adjuvants immunologiques, Anti-infectieux, Extraits de plantes.
- traitement médicamenteux : Infections à VIH, Syndrome d'immunodéficience acquise.
- Adulte, Adulte d'âge moyen, Animaux, Bactéries à Gram positif, Betula, Candida albicans, Fabaceae, Femelle, Ghana, Humains, Jeune adulte, Mâle, Souris, Souris de lignée ICR, Tests de sensibilité microbienne.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Acquired Immunodeficiency Syndrome (drug therapy), Acquired Immunodeficiency Syndrome (immunology), Adjuvants, Immunologic (administration & dosage), Adjuvants, Immunologic (pharmacology), Adult, Animals, Anti-Infective Agents (administration & dosage), Anti-Infective Agents (pharmacology), Betula (chemistry), Candida albicans (drug effects), Fabaceae (chemistry), Female, Ghana, Gram-Positive Bacteria (drug effects), HIV Infections (drug therapy), HIV Infections (immunology), Humans, Male, Mice, Mice, Inbred ICR, Microbial Sensitivity Tests, Middle Aged, Plant Extracts (administration & dosage), Plant Extracts (pharmacology), Young Adult.
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Anti-Infective Agents, Plant Extracts.
- chemical , pharmacology : Plant Extracts.
- geographic : Ghana.
- chemistry : Betula, Fabaceae.
- drug effects : Candida albicans, Gram-Positive Bacteria.
- drug therapy : Acquired Immunodeficiency Syndrome, HIV Infections.
- immunology : Acquired Immunodeficiency Syndrome, HIV Infections.
- chemical , pharmacology : Adjuvants, Immunologic, Anti-Infective Agents.
- Adult, Animals, Female, Humans, Male, Mice, Mice, Inbred ICR, Microbial Sensitivity Tests, Middle Aged, Young Adult.
Abstract
HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of
A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method.
The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as
The
Url:
PubMed: 25371579
PubMed Central: 4202435
Affiliations:
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Le document en format XML
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Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Dickson, Rita" sort="Dickson, Rita" uniqKey="Dickson R" first="Rita" last="Dickson">Rita Dickson</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Gbedema, Stephen Yao" sort="Gbedema, Stephen Yao" uniqKey="Gbedema S" 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Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author></analytic><series><title level="j">African Journal of Traditional, Complementary, and Alternative Medicines</title><idno type="eISSN">0189-6016</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acquired Immunodeficiency Syndrome (drug therapy)</term><term>Acquired Immunodeficiency Syndrome (immunology)</term><term>Adjuvants, Immunologic (administration & dosage)</term><term>Adjuvants, Immunologic (pharmacology)</term><term>Adult</term><term>Animals</term><term>Anti-Infective Agents (administration & dosage)</term><term>Anti-Infective Agents (pharmacology)</term><term>Betula (chemistry)</term><term>Candida albicans (drug effects)</term><term>Fabaceae (chemistry)</term><term>Female</term><term>Ghana</term><term>Gram-Positive Bacteria (drug effects)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (immunology)</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (pharmacology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Adjuvants immunologiques (pharmacologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anti-infectieux (administration et posologie)</term><term>Anti-infectieux (pharmacologie)</term><term>Bactéries à Gram positif ()</term><term>Betula ()</term><term>Candida albicans ()</term><term>Extraits de plantes (administration et posologie)</term><term>Extraits de plantes (pharmacologie)</term><term>Fabaceae ()</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Infections à VIH (immunologie)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Jeune adulte</term><term>Mâle</term><term>Souris</term><term>Souris de lignée ICR</term><term>Syndrome d'immunodéficience acquise (immunologie)</term><term>Syndrome d'immunodéficience acquise (traitement médicamenteux)</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Anti-Infective Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Anti-infectieux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Betula</term><term>Fabaceae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Candida albicans</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term><term>Syndrome d'immunodéficience acquise</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Anti-infectieux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Anti-Infective Agents</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term><term>Syndrome d'immunodéficience acquise</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Bactéries à Gram positif</term><term>Betula</term><term>Candida albicans</term><term>Fabaceae</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Souris</term><term>Souris de lignée ICR</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of <italic>Betula alba</italic> (BA) and <italic>Sutherlandia frutescens</italic> (SF) decoctions used in the management of HIV/AIDS in Ghana.</p></sec><sec sec-type="materials|methods"><title>Materials and Methods</title><p>A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method.</p></sec><sec sec-type="results"><title>Results</title><p>The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as <italic>Candida albicans</italic> (MIC 0.607 to 3.062 mg/ml). Phytochemicals present in both plants include saponins, terpenoids and coumarins.</p></sec><sec sec-type="conclusions"><title>Conclusion</title><p>The <italic>Betula alba</italic> and <italic>Sutherlandia frutescens</italic> decoctions have interesting immunostimulatory and antimicrobial properties and hence could be useful in the management of HIV/AIDS and associated opportunistic infections.</p></sec></div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Koffuor, George Asumeng" sort="Koffuor, George Asumeng" uniqKey="Koffuor G" first="George Asumeng" last="Koffuor">George Asumeng Koffuor</name></noRegion><name sortKey="Dapaah, Gabriel" sort="Dapaah, Gabriel" uniqKey="Dapaah G" first="Gabriel" last="Dapaah">Gabriel Dapaah</name><name sortKey="Dickson, Rita" sort="Dickson, Rita" uniqKey="Dickson R" first="Rita" last="Dickson">Rita Dickson</name><name sortKey="Ekuadzi, Edmund" sort="Ekuadzi, Edmund" uniqKey="Ekuadzi E" first="Edmund" last="Ekuadzi">Edmund Ekuadzi</name><name sortKey="Gbedema, Stephen Yao" sort="Gbedema, Stephen Yao" uniqKey="Gbedema S" first="Stephen Yao" last="Gbedema">Stephen Yao Gbedema</name><name sortKey="Otoo, Lydia Francisca" sort="Otoo, Lydia Francisca" uniqKey="Otoo L" first="Lydia Francisca" last="Otoo">Lydia Francisca Otoo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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